Rosie O’Donnell – 64 Lbs
Rosie O’Donnell is a superstar of film, stage, and comedy no matter what her weight is. That was good for her too, considering she struggled with her weight for most of her career. She built her career on wit and personality and even had stints as a host on “The View” and of her eponymous show.

But after several methods didn’t work and suffering a heart attack, O’Donnell decided to move a little smarter than usual. She got gastric bypass surgery and dropped an impressive 64 pounds by 2013. She was looking pretty lean in her role on the 2021 series “The L Word: Generation Q.”